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Tetracycline treatment does not eradicate Mycoplasma genitalium

¹ Department of Dermatology and Venereology, Örebro University Hospital, Örebro, Sweden
² Department of Clinical Microbiology and Immunology, Örebro University Hospital, Örebro, Sweden
³ Statens Serum Institut, Mycoplasma Laboratory, Copenhagen, Denmark

Correspondence to:
Lars Falk, Department of Dermatology and Venereology, Örebro University Hospital, SE-701 85 Örebro, Sweden;
lars.falk{at}orebroll.se

ABSTRACT
Objectives: To study the treatment efficacy of tetracyclines and azithromycin in Mycoplasma genitalium positive patients attending an STD clinic.

Methods: All M genitalium positive patients (34 men and 26 women) attending an STD clinic during a 6 month period were treated with antibiotics. All patients known to be partners of M genitalium positive patients and those who were M genitalium positive, but not initially treated, were treated with azithromycin. Patients with urethritis and/or cervicitis were treated with tetracyclines before their M genitalium status was known.

Results: 10 of 14 women (71%) and 10 of 16 men (63%) treated with tetracyclines were M genitalium positive at follow up, whereas all patients treated with azithromycin (16 men and 20 women) were M genitalium negative, at the 4 week follow up visit.

Conclusions: These results suggest that tetracyclines are not sufficient to eradicate M genitalium. Randomised controlled treatment trials are urgently needed.

Keywords: sexually transmitted diseases; Mycoplasma infections

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