HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: sti.2006.022772v1 83/5/419    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Thomsen, S. C Articles by Hobbs, M. M Search for Related Content PubMed PubMed Citation Articles by Thomsen, S. C Articles by Hobbs, M. M

Randomised controlled trial on whether advance knowledge of prostate-specific antigen testing improves participant reporting of unprotected sex

¹ Family Health International, Research Triangle Park, North Carolina, USA
² International Centre for Reproductive Health, Mombasa, Kenya
³ Family Health International, Nairobi, Kenya
⁴ University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Correspondence to:
Dr M F Gallo
Centers for Disease Control and Prevention, Division of Reproductive Health, 4770 Buford Highway, NE, MS K-34, Atlanta, GA 30341, USA; mgallo{at}cdc.gov

Objectives: To determine whether the process of informing research participants that they would be tested for the presence of a biological marker of semen exposure would reduce bias in their reports of unprotected sex.

Methods: A randomised trial of 210 female sex workers from Mombasa, Kenya, was conducted, where half the group had advance knowledge (via the request for informed consent) that they would be tested for prostate-specific antigen (PSA) in their vaginal fluid before they reported on sex and condom use for the past 48 h. The other half were invited to participate (via additional informed consent) in the test for PSA after they had already consented to be questioned and reported on these sexual behaviours. A trained nurse instructed participants to self-swab to collect vaginal fluid specimens, which were tested for PSA using ELISA.

Results: Reporting of unprotected sex did not differ between those with advance knowledge of the test for PSA and those without this knowledge (14.3% v 11.4%, respectively; p = 0.27). Surprisingly, more women with advance knowledge (15.8%) had discrepant self reports and PSA results than women without advance knowledge (9.1%); however, the difference was not statistically significant (OR 1.9; 95% CI 0.8 to 4.5).

Conclusions: Knowing that one’s answers to a questionnaire could be verified with a biological marker of semen exposure did not make respondents more likely to report unprotected sex.

Abbreviations: PSA, prostate-specific antigen