Accession Number	<strong>00002030-200105040-00009</strong>.
Author	Auvert, Bertran a,b; Ballard, Ron c; Campbell, Catherine d; Carael, Michel e; Carton, Matthieu a; Fehler, Glenda c; Gouws, Eleanor f; MacPhail, Catherine g; Taljaard, Dirk g; Van Dam, Johannes h; Williams, Brian g
Institution	From (a)INSERM U88, Saint-Maurice, the (b)Hopital Ambroise Pare, Boulogne-Billancourt, France, the (c)Reference Centre for Sexually Transmitted Diseases, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg, South Africa, the (d)London Schools of Economics and Political Science, London, UK, the (e)UNAIDS, Geneva, Switzerland, the (f)Medical Research Council, Durban, the (g)Council for Scientific and Industrial Research, Johannesburg, South Africa and the (h)Population Council, Washington DC, USA.
Title	HIV infection among youth in a South African mining town is associated with herpes simplex virus-2 seropositivity and sexual behaviour.[Miscellaneous Article]
Source	AIDS. 15(7):885-898, May 4, 2001.
Abstract	Objectives: To determine the seroprevalence of HIV and herpes simplex virus-2 (HSV-2) by age and gender among young people aged 14-24 years in a South African town and to identify risk factors for HIV infection. Design: A community-based, cross-sectional study was conducted on a random sample of men (n = 723) and women (n = 784) living in a township in the Carletonville district of South Africa. Methods: Potential demographic and behavioural risk factors associated with HIV were recorded by questionnaire and biological tests were performed on serum and urine. Data analysis was performed using multivariate logistic regression. Results: Among men and women the prevalence of HIV infection was 9.4 and 34.4%, respectively, and of positive HSV-2 serology was 17.0 and 53.3%, respectively. Among 24-year-old women the prevalence of HIV was 66.7% [95% confidence interval (CI), 54.6-77.3%]. HSV-2 seropositivity was a strong independent risk factor for HIV infection with odds ratios of 5.3 (95% CI, 2.7-10.3) for men and 8.4 (95% CI, 4.9-14.2) for women. There was no independent effect of age at first sex or serological markers of other sexually transmitted infections on HIV infection. Conclusions: HIV infection among young women increases rapidly after the onset of sexual activity and reaches extremely high levels by 24 years of age. These findings suggest that rates of HIV transmission from men to women are high and that HSV-2 plays a major role in the spread of HIV in this population. (C) 2001 Lippincott Williams & Wilkins, Inc.